While explosively stripping the evil pirate LeChuck of his demonic mojo, Guybrush Threepwood inadvertently infects the entire Caribbean with the arch-fiend's expelled voodoo, which threatens to transform buccaneers into unruly pirate monsters. Pursued by a notorious cut-throat Pirate Hunter and a creepy French Physician who believes that Guybrush's eerily-infected hand holds the secret of eternal life, Threepwood sails the seven seas in search of La Esponja Grande, a legendary sea sponge with unparalleled voodoo exfoliating abilities. But little does Guybrush know, his quest is part of a larger, more sinister plot, and good and evil are not always as they seem...
Who can Guybrush trust? Where can he turn? Everything you think you know will be challenged as Tales of Monkey Island builds to its unexpected finale!